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There are anti-virus applications, but the definitions tend to be for Windows viruses, which rather defeats the purpose, although it could be argued that they safeguard PCs networked with a Mac.
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I'm currently using linux ubuntu 9.04 on dual boot laptop. Much the forums advice I have come across lately encourages linux users to have an antivirus app installed mainly because it protects other (windows) users.
One site says you need an AV:
"to scan a Windows drive in your PC
to scan a Windows-based network attached server or hard drive
to scan Windows machines over a network
to scan files you are going to send to other people
to scan e-mail you are going to forward to other people
Linux virus infections are theoretically possible"
Doesn't the same apply to Macs?
For cleaning Macs a la CCleaner, I came acoss
this.